Identification of 57-91-0

• Name:

• Estra-1,3,5(10)-triene-3,17-diol,(17a)- (Related Reference)

• EINECS:

• 200-354-8

• Synonyms:

• 17a-Estradiol (8CI); 1,3,5-Estratriene-3,17a-diol; 13b-Methyl-1,3,5(10)-gonatriene-3,17a-diol; 17-Epiestradiol; 17a-Oestradiol; 3,17-Dihydroxyestratriene; 3,17a-Dihydroxyestra-1,3,5(10)-triene; 3,17a-Dihydroxyoestra-1,3,5(10)-triene; Alfatradiol; Epiestrol; Estra-1,3,5(10)-triene-3,17a-diol; NSC 20293; Oestra-1,3,5(10)-triene-3,17a-diol; a-Estradiol;

• InChI:

• InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17-,18+/m1/s1

• This structure is also available as a 2d Mol file

• Risk Codes:

• R40;R48

• Safety Statements:

• 53-45-24/25-22

• MSDS infomation:

• Estra-1,3,5(10)-triene-3,17-diol,(17a)- (57-91-0).msds

• Appearance:

• powder

• Molecular Weight:

• 272.38196

• Density:

• 1.17 g/cm³

• Boiling Point:

• 445.9 °C at 760 mmHg

• Melting Point:

• 176-180 °C(lit.)

• Flash Point:

• 209.6 °C

• Storage Temperature:

• 0-6°C

• Refractive index:

• 1.599

• Solubility:

• ethanol: 50 mg/mL, clear, colorless

• Biological Activity:

• Endogenous estrogen receptor ligand (K i values are 0.2 and 1.2 nM for ER α and ER β receptors respectively).

• Usage:

• Estradiol (known as α-Estradiol or 17 α-Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture. 17-Εstradiol and its selective receptor, ER-X, are not part of a classical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain. 17-Estradiol may have enormous implications for hormone replacement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer’s disease and ischemic stroke.