Identification of 57-91-0
Name:
EINECS:
200-354-8
Synonyms:
17a-Estradiol (8CI); 1,3,5-Estratriene-3,17a-diol; 13b-Methyl-1,3,5(10)-gonatriene-3,17a-diol; 17-Epiestradiol; 17a-Oestradiol; 3,17-Dihydroxyestratriene; 3,17a-Dihydroxyestra-1,3,5(10)-triene; 3,17a-Dihydroxyoestra-1,3,5(10)-triene; Alfatradiol; Epiestrol; Estra-1,3,5(10)-triene-3,17a-diol; NSC 20293; Oestra-1,3,5(10)-triene-3,17a-diol; a-Estradiol;
InChI:
InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17-,18+/m1/s1
This structure is also available as a 2d Mol file
Risk Codes:
Safety Statements:
MSDS infomation:
Appearance:
powder
Molecular Weight:
272.38196
Density:
1.17 g/cm3
Boiling Point:
445.9 °C at 760 mmHg
Melting Point:
176-180 °C(lit.)
Flash Point:
209.6 °C
Storage Temperature:
0-6°C
Refractive index:
1.599
Solubility:
ethanol: 50 mg/mL, clear, colorless
Biological Activity:
Endogenous estrogen receptor ligand (K i values are 0.2 and 1.2 nM for ER α and ER β receptors respectively).
Usage:
Estradiol (known as α-Estradiol or 17 α-Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture. 17-Εstradiol and its selective receptor, ER-X, are not part of a classical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain. 17-Estradiol may have enormous implications for hormone replacement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer’s disease and ischemic stroke.